Weisberger on atorvastatin vs simvastatin side effects. To the editor in their commentary on generic drug use, alldredge and kayser 1 p233 state the following. Bliss, rph, mba and the healthline editorial team side. Lipitor atorvastatin and zocor simvastatin are belong to the statin family of drugs that work to lower blood cholesterol, thereby treating a host of cardiovascular conditions, including congestive heart failure prevention. Simvastatin is sold under the name zocor, and lipitor as atorvastatin calcium. To study the effect of high dose atorvastatin 40 mg versus 80.
Both drugs were given in a dose of 10 mg po once daily. Lipitor atorvastatin is a good option for people who have high cholesterol and diabetes. Furthermore, atorvastatin is prone to typeii diabetes mellitus, and patients with hepatic dysfunction should avoid atorvastatin as it alters the normal sgpt and others liver functioning enzymes. Oxygen free radical release in human failing myocardium is associ. Lipitor atorvastatin improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease. Its available as a generic drug and can be used in combination with other cholesterol lowering drugs. Primary objective was to compare the effects of atorvastatin 40 mg vs 80 mg on ldlc in indian patients with atherosclerotic dyslipidemia.
This was a cohort observational populationbased study conducted at hamad medical hospital and primary. Zocor, on the other hand is called simvastatin with a empirical formula of c25h38o5 and a molecular weight of 418. Atorvastatin and simvastatin are parts of a group of drugs called statins that revolutionized cholesterol management and heart disease prevention atorvastatin and simvastatin both target the same chemical in the body to reduce drastically the bloodstream levels of ldl lowdensity lipoprotein, or bad cholesterol, which lowers the risk it will clog up arteries, a central cause of. Crp of individuals taking atorvastatin was significantly lower than when they were taking simvastatin median 1. The older statins lovastatin, pravastatin, and simvastatin are naturally derived. Results the combination of atorvastatinezetimibe resulted in lower levels of ldlc than atorvastatin monotherapy 63. It should be noted that higher doses can produce more dramatic results. It reduces ldl and total cholesterol levels while increasing levels of hdl cholesterol. Generically, lipitor is called atorvastatin calcium and its empirical formula is c33h34 fn2o52ca3h2o with a molecular weight of 1209. Comparison of costeffectiveness, safety, and efficacy of. Efficacy of atorvastatin compared with simvastatin in. Aug 03, 2019 atorvastatin vs simvastatin which is better. Comparing hmgacoa reductase inhibitors wiley online library.
While zetia does lower cholesterol, there is to date no convincing evidence that it saves lives. This observational study examined the medical records of 271 patients who were treated at the guangdong cardiovascular institute from april 2004 to february 2008. While the former drug is also available as a generic, the latter is not. Pdf atorvastatin compared with simvastatinbased therapies in the. Crestor vs lipitor vs zocor which statin is better for you. Fish oil epa dietary supplement or prescription vascepa no side effects except burping with dietary supplements, but less effective. Why isnt rosuvastatin prescribed more frequently than. Pleiotropic effects of statins on the cardiovascular.
Compared with nonstatin lipid lowering agents, ryr preparations appeared superior to nicotinate and fish oils, but equal to or less effective than fenofibrate and gemfibrozil. Comparison of effects of simvastatin versus atorvastatin on. Compare lipitor vs simvastatin comprehensive analysis by. Sample sizes were calculated based on the 2sided dunnetts test with a significance level of 5% and a standard deviation of % to detect differences in ldl cholesterol reductions of 8% e. Myalgia association with atorvastatin, rosuvastatin and. Atorvastatin lipitor is an inexpensive drug that lowers levels of cholesterol and triglycerides in the blood. Currently, there are six statin drugs available on the market pitavastatin, atorvastatin, rosuvastatin, pravastatin, simvastatin and fluvastatin.
Simvastatin is part of a group of drugs known as statins that reduce levels of ldl cholesterol in the blood while increasing levels. The lipid modification effects appeared to be similar to pravastatin, simvastatin, lovastatin, atorvastatin, or fluvastatin. Highdose atorvastatin vs usualdose simvastatin for secondary prevention after myocardial infarction. Statins are the only cholesterol drugs that have been clearly shown to reduce mortality that is, to save lives. Most popular statins indeed, the bestknown statins are crestor, lipitor, and zocor quite probably because they have the greatest effect on cholesterol levels. For the prevention of cardiovascular disease, statins are a firstline treatment. In the secondary analysis, which compared the efficacy of atorvastatin 10 mg with that of simvastatin 10 mg, the mean decrease in ldl cholesterol was significantly greater p atorvastatin 10 mg than for simvastatin 10 mg 37.
Jun 10, 2006 the maximum price of simvastatin 40 mg is now up to six times cheaper than atorvastatin. Pfizer inc despite a significant cost differential and no apparent clinical differences in efficacy and safety. Comparative dose efficacy study of atorvastatin versus. Atorvastatin belongs to a group of drugs called hmg coa reductase inhibitors.
Drug interactions with atorvastatin oral and simvastatin oral. Patients had received either 40 mg simvastatin n 128 or 20 mg atorvastatin n 143, daily, for a period of at least 6 months following pci. A comparative evaluation of safety and efficacy of. Hydrophilicity pravastatin and rosuvastatin originates from the. Drugs az pill identifier supplements symptom checker diseases dictionary media. For a desired reduction of ldlc greater than 42%, simvastatin zocor, atorvastatin lipitor, or rosuvastatin crestor would be needed. Atorvastatin vs simvastatin side effects answers on healthtap. The differences between these two treatments are the differences in the medications themselves. In the secondary analysis, which compared the efficacy of atorvastatin 10 mg with that of simvastatin 10 mg, the mean decrease in ldl cholesterol was significantly greater p pravastatin, and simvastatin for managing dyslipidemia among diabetic patients with and without metabolic syndrome mets. Disparate effects of atorvastatin compared with simvastatin. Mevacor lovastatin can improve cholesterol, but its not as strong as other statin medicines. Conclusions compared with simvastatin, atorvastatin reduced hscrp and its variability in type 2 diabetic patients.
Atorvastatin, sold under the brand name lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. Compare lipitor vs simvastatin headtohead with other drugs for uses, ratings, cost, side effects, interactions and more. Read about statins medicines that lower the level of lowdensity lipoprotein ldl. Atorvastatin may also reduce the risk of heart attack or stroke in patients with risk factors for heart disease. You need to have liver tests, muscle problems including rhabdomyolysis, cognitive deficits with statins.
The renoprotective effects of simvastatin and atorvastatin i. Atorvastatin versus simvastatin tips and tricks from doctors. As of 2011, it is available in generic and brand versions. Ldl cholesterol is often referred to as bad cholesterol, and statins reduce.
Unfortunately, despite the fact that 80 mg atorvastatin was associated with a 46% reduction in the primary end point death, nonfatal mi, and tvr, the study was not nearly powered enough to assess this end point, because these events occurred in only 9 patients in the lowdose atorvastatin group compared with 5 events in the highdose group. In 2011, fewer prescriptions for generic simvastatin were written than for lipitor atorvastatin calcium. Myalgia prevalence was categorize according to the type of statin as 10% in atorvastatin group, 11. Despite relatively low baseline levels of ldl cholesterol in our study, 16 weeks of atorvastatin treatment produced a further reduction to a mean level of 72 mgdl 1. Anticoagulant effects of statins and their clinical implications.
Doctors give trusted answers on uses, effects, sideeffects, and cautions. However, data are lacking regarding the efficacy and safety of the 4 most commonly prescribed statins rosuvastatin, atorvastatin, pravastatin, and simvastatin for managing dyslipidemia among diabetic patients. May, 2020 atorvastatin and simvastatin are medications that treat high blood cholesterol and triglycerides. Whether atorvastatin has a stronger antioxidant effect than other statins is uncertain.
Pravachol pravastatin can improve cholesterol, but its not as. Zocor simvastatin dose, indications, adverse effects. Compare atorvastatin vs lovastatin vs pravastatin vs. Secondary objectives were to compare the effects of atorvastatin 40 mg vs 80 mg on hdlc and triglycerides and also comparing of side effects myopathy, hepatotoxicity and new onset diabetes mellitus of. Atorvastatin vs simvastatin uses, side effects, differences. Why physicians favored lipitor over simvastatin clinical. Impact of dual lipidlowering strategy with ezetimibe and.
Compare atorvastatin vs simvastatin headtohead with other drugs for uses, ratings, cost, side effects, interactions and more. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks. Pdf we compared atorvastatin with simvastatinbased therapies in a prospective observational study of 201 patients with severe. Subanalysis showed that atorvastatin was associated with reduced total testosterone 11. In general, both these medications lower bad cholesterol and triglycerides and increase good cholesterol in the process. Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking. Highdose atorvastatin in acute coronary and cerebrovascular.
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